Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3030340..3030837 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P9N54_RS14765 Protein ID WP_001173343.1
Coordinates 3030340..3030513 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag P9N54_RS14770 Protein ID WP_000398619.1
Coordinates 3030541..3030837 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS14755 (3027010) 3027010..3028467 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
P9N54_RS14760 (3028704) 3028704..3030221 + 1518 WP_001295074.1 lysine--tRNA ligase -
P9N54_RS14765 (3030340) 3030340..3030513 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P9N54_RS14770 (3030541) 3030541..3030837 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P9N54_RS14775 (3031064) 3031064..3031336 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
P9N54_RS14780 (3031348) 3031348..3031578 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
P9N54_RS14785 (3031759) 3031759..3033390 + 1632 WP_001216461.1 sensor histidine kinase -
P9N54_RS14790 (3033387) 3033387..3034106 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T276201 WP_001173343.1 NZ_CP121294:c3030513-3030340 [Escherichia coli O155:H21]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT276201 WP_000398619.1 NZ_CP121294:c3030837-3030541 [Escherichia coli O155:H21]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References