Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2782944..2783530 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag P9N54_RS13625 Protein ID WP_042014162.1
Coordinates 2783300..2783530 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag P9N54_RS13620 Protein ID WP_000593555.1
Coordinates 2782944..2783303 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS13595 (2779076) 2779076..2780020 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
P9N54_RS13600 (2780017) 2780017..2780850 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
P9N54_RS13605 (2780850) 2780850..2781614 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
P9N54_RS13610 (2781611) 2781611..2782417 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
P9N54_RS13615 (2782423) 2782423..2782824 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
P9N54_RS13620 (2782944) 2782944..2783303 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P9N54_RS13625 (2783300) 2783300..2783530 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
P9N54_RS13630 (2783634) 2783634..2784758 - 1125 WP_001314210.1 ABC transporter permease -
P9N54_RS13635 (2784758) 2784758..2787493 - 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T276200 WP_042014162.1 NZ_CP121294:c2783530-2783300 [Escherichia coli O155:H21]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT276200 WP_000593555.1 NZ_CP121294:c2783303-2782944 [Escherichia coli O155:H21]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References