Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2761437..2762237 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag P9N54_RS13500 Protein ID WP_136721175.1
Coordinates 2761437..2761964 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag P9N54_RS13505 Protein ID WP_001277108.1
Coordinates 2761971..2762237 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS13475 (2756512) 2756512..2757279 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
P9N54_RS13480 (2757276) 2757276..2758553 - 1278 WP_000803771.1 branched chain amino acid ABC transporter permease LivM -
P9N54_RS13485 (2758550) 2758550..2759476 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
P9N54_RS13490 (2759524) 2759524..2760633 - 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
P9N54_RS13495 (2761057) 2761057..2761440 + 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
P9N54_RS13500 (2761437) 2761437..2761964 - 528 WP_136721175.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
P9N54_RS13505 (2761971) 2761971..2762237 - 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
P9N54_RS13510 (2762387) 2762387..2763490 - 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
P9N54_RS13515 (2763761) 2763761..2764615 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
P9N54_RS13520 (2764860) 2764860..2765918 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
P9N54_RS13525 (2765911) 2765911..2766579 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19740.77 Da        Isoelectric Point: 7.7438

>T276199 WP_136721175.1 NZ_CP121294:c2761964-2761437 [Escherichia coli O155:H21]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENEYAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT276199 WP_001277108.1 NZ_CP121294:c2762237-2761971 [Escherichia coli O155:H21]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References