Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2501611..2502236 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P9N54_RS12280 Protein ID WP_000911330.1
Coordinates 2501611..2502009 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag P9N54_RS12285 Protein ID WP_000450524.1
Coordinates 2502009..2502236 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS12260 (2497489) 2497489..2497689 + 201 WP_000383836.1 YpfN family protein -
P9N54_RS12265 (2497799) 2497799..2498497 - 699 WP_000679823.1 esterase -
P9N54_RS12270 (2498571) 2498571..2500586 - 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
P9N54_RS12275 (2500601) 2500601..2501464 - 864 WP_001267508.1 neutral zinc metallopeptidase -
P9N54_RS12280 (2501611) 2501611..2502009 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
P9N54_RS12285 (2502009) 2502009..2502236 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
P9N54_RS12290 (2502390) 2502390..2503103 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
P9N54_RS12295 (2503316) 2503316..2504350 - 1035 WP_136721100.1 outer membrane protein assembly factor BamC -
P9N54_RS12300 (2504367) 2504367..2505245 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
P9N54_RS12305 (2505391) 2505391..2505963 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
P9N54_RS12310 (2505963) 2505963..2506433 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T276198 WP_000911330.1 NZ_CP121294:c2502009-2501611 [Escherichia coli O155:H21]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT276198 WP_000450524.1 NZ_CP121294:c2502236-2502009 [Escherichia coli O155:H21]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References