Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2248939..2249534 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag P9N54_RS11030 Protein ID WP_000239579.1
Coordinates 2249184..2249534 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag P9N54_RS11025 Protein ID WP_001223208.1
Coordinates 2248939..2249190 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS11015 (2244603) 2244603..2248382 + 3780 WP_000060901.1 autotransporter assembly complex protein TamB -
P9N54_RS11020 (2248385) 2248385..2248726 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
P9N54_RS11025 (2248939) 2248939..2249190 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
P9N54_RS11030 (2249184) 2249184..2249534 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
P9N54_RS11035 (2249613) 2249613..2250143 - 531 WP_000055072.1 inorganic diphosphatase -
P9N54_RS11040 (2250453) 2250453..2251409 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
P9N54_RS11045 (2251719) 2251719..2253221 + 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
P9N54_RS11050 (2253235) 2253235..2254257 + 1023 WP_001339490.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T276197 WP_000239579.1 NZ_CP121294:2249184-2249534 [Escherichia coli O155:H21]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT276197 WP_001223208.1 NZ_CP121294:2248939-2249190 [Escherichia coli O155:H21]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References