Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1867223..1867877 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag P9N54_RS09180 Protein ID WP_000244772.1
Coordinates 1867223..1867630 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P9N54_RS09185 Protein ID WP_000354046.1
Coordinates 1867611..1867877 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS09160 (1863180) 1863180..1864913 - 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -
P9N54_RS09165 (1864919) 1864919..1865629 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P9N54_RS09170 (1865654) 1865654..1866550 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P9N54_RS09175 (1866662) 1866662..1867183 + 522 WP_001055874.1 flavodoxin FldB -
P9N54_RS09180 (1867223) 1867223..1867630 - 408 WP_000244772.1 protein YgfX Toxin
P9N54_RS09185 (1867611) 1867611..1867877 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P9N54_RS09190 (1868120) 1868120..1869100 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
P9N54_RS09195 (1869177) 1869177..1869836 - 660 WP_000250274.1 hemolysin III family protein -
P9N54_RS09200 (1870000) 1870000..1870311 - 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
P9N54_RS09205 (1870356) 1870356..1871789 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
P9N54_RS09210 (1871846) 1871846..1872589 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T276196 WP_000244772.1 NZ_CP121294:c1867630-1867223 [Escherichia coli O155:H21]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT276196 WP_000354046.1 NZ_CP121294:c1867877-1867611 [Escherichia coli O155:H21]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References