Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1517150..1517768 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P9N54_RS07505 Protein ID WP_001291435.1
Coordinates 1517150..1517368 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P9N54_RS07510 Protein ID WP_000344800.1
Coordinates 1517394..1517768 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS07470 (1512439) 1512439..1513011 + 573 WP_000779831.1 YbaY family lipoprotein -
P9N54_RS07475 (1513042) 1513042..1513353 - 312 WP_000409911.1 MGMT family protein -
P9N54_RS07485 (1513732) 1513732..1514085 + 354 WP_000878140.1 DUF1428 domain-containing protein -
P9N54_RS07490 (1514127) 1514127..1515677 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P9N54_RS07495 (1515841) 1515841..1516311 - 471 WP_000136192.1 YlaC family protein -
P9N54_RS07500 (1516427) 1516427..1516978 - 552 WP_000102568.1 maltose O-acetyltransferase -
P9N54_RS07505 (1517150) 1517150..1517368 - 219 WP_001291435.1 HHA domain-containing protein Toxin
P9N54_RS07510 (1517394) 1517394..1517768 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P9N54_RS07515 (1518314) 1518314..1521463 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P9N54_RS07520 (1521486) 1521486..1522679 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T276194 WP_001291435.1 NZ_CP121294:c1517368-1517150 [Escherichia coli O155:H21]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT276194 WP_000344800.1 NZ_CP121294:c1517768-1517394 [Escherichia coli O155:H21]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References