Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1270377..1271015 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P9N54_RS06355 Protein ID WP_000813794.1
Coordinates 1270377..1270553 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P9N54_RS06360 Protein ID WP_136721302.1
Coordinates 1270599..1271015 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS06335 (1265996) 1265996..1267171 - 1176 WP_001236319.1 BenE family transporter YdcO -
P9N54_RS06340 (1267263) 1267263..1267799 + 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
P9N54_RS06345 (1267872) 1267872..1269833 + 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P9N54_RS06350 (1269925) 1269925..1270155 - 231 WP_000494244.1 YncJ family protein -
P9N54_RS06355 (1270377) 1270377..1270553 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P9N54_RS06360 (1270599) 1270599..1271015 + 417 WP_136721302.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P9N54_RS06365 (1271094) 1271094..1272500 + 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
P9N54_RS06370 (1272745) 1272745..1273890 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
P9N54_RS06375 (1273908) 1273908..1274921 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
P9N54_RS06380 (1274922) 1274922..1275863 + 942 WP_001251319.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG/tssI / vgrG/tssI 1264691..1317658 52967
- flank IS/Tn - - 1264691..1265956 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T276192 WP_000813794.1 NZ_CP121294:1270377-1270553 [Escherichia coli O155:H21]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15245.69 Da        Isoelectric Point: 5.1738

>AT276192 WP_136721302.1 NZ_CP121294:1270599-1271015 [Escherichia coli O155:H21]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAKAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References