Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 4509397..4510352 | Replicon | chromosome |
| Accession | NZ_CP121270 | ||
| Organism | Gordonia hongkongensis strain RL-LY01 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | P9A14_RS20250 | Protein ID | WP_165629536.1 |
| Coordinates | 4509397..4509972 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | P9A14_RS20255 | Protein ID | WP_165629535.1 |
| Coordinates | 4509969..4510352 (-) | Length | 128 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P9A14_RS20225 (P9A14_20225) | 4505651..4506658 | + | 1008 | WP_205333373.1 | LacI family DNA-binding transcriptional regulator | - |
| P9A14_RS20230 (P9A14_20230) | 4506662..4506979 | - | 318 | WP_165629539.1 | DUF2470 domain-containing protein | - |
| P9A14_RS20235 (P9A14_20235) | 4506972..4507703 | - | 732 | WP_078113769.1 | tyrosine-protein phosphatase | - |
| P9A14_RS20240 (P9A14_20240) | 4507796..4508428 | + | 633 | WP_165629538.1 | flavin reductase family protein | - |
| P9A14_RS20245 (P9A14_20245) | 4508453..4509400 | - | 948 | WP_165629537.1 | PfkB family carbohydrate kinase | - |
| P9A14_RS20250 (P9A14_20250) | 4509397..4509972 | - | 576 | WP_165629536.1 | zeta toxin family protein | Toxin |
| P9A14_RS20255 (P9A14_20255) | 4509969..4510352 | - | 384 | WP_165629535.1 | hypothetical protein | Antitoxin |
| P9A14_RS20260 (P9A14_20260) | 4510476..4511024 | - | 549 | WP_068970820.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
| P9A14_RS20265 (P9A14_20265) | 4511021..4511515 | - | 495 | WP_165629534.1 | peptide-methionine (R)-S-oxide reductase MsrB | - |
| P9A14_RS20270 (P9A14_20270) | 4511672..4512895 | - | 1224 | WP_165630783.1 | acyl-CoA dehydrogenase family protein | - |
| P9A14_RS20275 (P9A14_20275) | 4512974..4514062 | - | 1089 | WP_165629533.1 | VOC family protein | - |
| P9A14_RS20280 (P9A14_20280) | 4514309..4515202 | + | 894 | WP_165629532.1 | acetaldehyde dehydrogenase (acetylating) | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21176.30 Da Isoelectric Point: 10.1705
>T276175 WP_165629536.1 NZ_CP121270:c4509972-4509397 [Gordonia hongkongensis]
VTPRLDLVVGCNGAGKSTLVERHLQPLLHVPFVNADLIARQRWPDSAEAHSYDAARLAAATRDTLIERGTSFIAETVFSH
PSKLELIERAHTAGYRVALHVVMIPEALAVHRVRLRVDSGGHAVAEVKIRERFRRLWPLVRTAIARSDLATVYANERPTT
RIVARYVDGLVAGVPDWPDWTPGALTDTKAR
VTPRLDLVVGCNGAGKSTLVERHLQPLLHVPFVNADLIARQRWPDSAEAHSYDAARLAAATRDTLIERGTSFIAETVFSH
PSKLELIERAHTAGYRVALHVVMIPEALAVHRVRLRVDSGGHAVAEVKIRERFRRLWPLVRTAIARSDLATVYANERPTT
RIVARYVDGLVAGVPDWPDWTPGALTDTKAR
Download Length: 576 bp
Antitoxin
Download Length: 128 a.a. Molecular weight: 13669.10 Da Isoelectric Point: 5.2284
>AT276175 WP_165629535.1 NZ_CP121270:c4510352-4509969 [Gordonia hongkongensis]
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRQRVEAALAGDLPGDVLTAEEAVVYDAEI
DAHLEARLATDDHVVRRASAGLSSVVVDDAGRLVEHRPDGTSVILEQ
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRQRVEAALAGDLPGDVLTAEEAVVYDAEI
DAHLEARLATDDHVVRRASAGLSSVVVDDAGRLVEHRPDGTSVILEQ
Download Length: 384 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|