Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4589698..4590314 Replicon chromosome
Accession NZ_CP121269
Organism Enterobacter hormaechei subsp. xiangfangensis strain F81Y

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P9J39_RS21825 Protein ID WP_017382676.1
Coordinates 4589698..4590069 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag P9J39_RS21830 Protein ID WP_015569912.1
Coordinates 4590072..4590314 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9J39_RS21810 (P9J39_21810) 4587198..4588100 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
P9J39_RS21815 (P9J39_21815) 4588097..4588732 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
P9J39_RS21820 (P9J39_21820) 4588729..4589658 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
P9J39_RS21825 (P9J39_21825) 4589698..4590069 - 372 WP_017382676.1 type II toxin-antitoxin system VapC family toxin Toxin
P9J39_RS21830 (P9J39_21830) 4590072..4590314 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
P9J39_RS21835 (P9J39_21835) 4590513..4591433 + 921 WP_063158447.1 alpha/beta hydrolase -
P9J39_RS21840 (P9J39_21840) 4591442..4592383 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
P9J39_RS21845 (P9J39_21845) 4592428..4592865 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
P9J39_RS21850 (P9J39_21850) 4592862..4593743 - 882 WP_003861949.1 virulence factor BrkB family protein -
P9J39_RS21855 (P9J39_21855) 4593737..4594336 - 600 WP_017694048.1 glucose-1-phosphatase -
P9J39_RS21860 (P9J39_21860) 4594455..4595255 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13737.88 Da        Isoelectric Point: 6.4882

>T276172 WP_017382676.1 NZ_CP121269:c4590069-4589698 [Enterobacter hormaechei subsp. xiangfangensis]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT276172 WP_015569912.1 NZ_CP121269:c4590314-4590072 [Enterobacter hormaechei subsp. xiangfangensis]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References