Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2301805..2302544 Replicon chromosome
Accession NZ_CP121269
Organism Enterobacter hormaechei subsp. xiangfangensis strain F81Y

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag P9J39_RS10950 Protein ID WP_278110266.1
Coordinates 2301805..2302290 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag P9J39_RS10955 Protein ID WP_003857131.1
Coordinates 2302278..2302544 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9J39_RS10920 (P9J39_10920) 2297303..2297917 + 615 WP_080337332.1 NUDIX hydrolase -
P9J39_RS10925 (P9J39_10925) 2298101..2298736 - 636 WP_015570517.1 DUF421 domain-containing protein -
P9J39_RS10930 (P9J39_10930) 2298746..2299192 - 447 WP_014069654.1 DUF3290 domain-containing protein -
P9J39_RS10935 (P9J39_10935) 2299621..2299949 - 329 Protein_2130 ISNCY family transposase -
P9J39_RS10940 (P9J39_10940) 2300204..2301169 + 966 WP_032648329.1 hypothetical protein -
P9J39_RS10945 (P9J39_10945) 2301185..2301754 + 570 WP_032648331.1 hypothetical protein -
P9J39_RS10950 (P9J39_10950) 2301805..2302290 - 486 WP_278110266.1 GNAT family N-acetyltransferase Toxin
P9J39_RS10955 (P9J39_10955) 2302278..2302544 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
P9J39_RS10960 (P9J39_10960) 2302608..2303537 - 930 WP_252011907.1 LysR family transcriptional regulator -
P9J39_RS10965 (P9J39_10965) 2303667..2305055 + 1389 WP_278110276.1 MFS transporter -
P9J39_RS10970 (P9J39_10970) 2305077..2306072 - 996 WP_017693414.1 DUF2891 domain-containing protein -
P9J39_RS10975 (P9J39_10975) 2306082..2307068 - 987 WP_017693413.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T276164 WP_278110266.1 NZ_CP121269:c2302290-2301805 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKTFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT276164 WP_003857131.1 NZ_CP121269:c2302544-2302278 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References