276158

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1359940..1360856 Replicon chromosome
Accession NZ_CP121266
Organism Bacillus subtilis strain 107105

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag P8R49_RS07225 Protein ID WP_003244695.1
Coordinates 1360110..1360856 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag P8R49_RS07220 Protein ID WP_003232646.1
Coordinates 1359940..1360110 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R49_RS07185 (P8R49_07185) 1356799..1357128 + 330 WP_014479562.1 XkdW family protein -
P8R49_RS07190 (P8R49_07190) 1357125..1357289 + 165 WP_014479563.1 XkdX family protein -
P8R49_RS07195 (P8R49_07195) 1357336..1358175 + 840 WP_014479564.1 phage-like element PBSX protein XepA -
P8R49_RS07200 (P8R49_07200) 1358228..1358497 + 270 WP_014479565.1 hemolysin XhlA family protein -
P8R49_RS07205 (P8R49_07205) 1358510..1358773 + 264 WP_014479566.1 phage holin -
P8R49_RS07210 (P8R49_07210) 1358786..1359679 + 894 WP_014479567.1 N-acetylmuramoyl-L-alanine amidase -
P8R49_RS07215 (P8R49_07215) 1359717..1359854 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
P8R49_RS07220 (P8R49_07220) 1359940..1360110 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
P8R49_RS07225 (P8R49_07225) 1360110..1360856 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
P8R49_RS07230 (P8R49_07230) 1360966..1361967 - 1002 WP_014479569.1 inorganic phosphate transporter -
P8R49_RS07235 (P8R49_07235) 1361980..1362597 - 618 WP_003218470.1 DUF47 domain-containing protein -
P8R49_RS07240 (P8R49_07240) 1362873..1364189 - 1317 WP_014479570.1 serine/threonine exchanger -
P8R49_RS07245 (P8R49_07245) 1364578..1365528 + 951 WP_014479571.1 ring-cleaving dioxygenase -
P8R49_RS07250 (P8R49_07250) 1365637..1365732 + 96 Protein_1365 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T276158 WP_003244695.1 NZ_CP121266:c1360856-1360110 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT276158 WP_003232646.1 NZ_CP121266:c1360110-1359940 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References