Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4293451..4294232 | Replicon | chromosome |
| Accession | NZ_CP121262 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain 013 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | P8621_RS20960 | Protein ID | WP_000626099.1 |
| Coordinates | 4293451..4293942 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | P8621_RS20965 | Protein ID | WP_001110452.1 |
| Coordinates | 4293939..4294232 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P8621_RS20925 (4289446) | 4289446..4290021 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| P8621_RS20935 (4290292) | 4290292..4290369 | - | 78 | Protein_4088 | helix-turn-helix domain-containing protein | - |
| P8621_RS20940 (4290460) | 4290460..4290792 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| P8621_RS20945 (4290864) | 4290864..4291241 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| P8621_RS20950 (4292274) | 4292274..4292348 | + | 75 | Protein_4091 | porin family protein | - |
| P8621_RS20955 (4292451) | 4292451..4293203 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| P8621_RS20960 (4293451) | 4293451..4293942 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| P8621_RS20965 (4293939) | 4293939..4294232 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| P8621_RS20970 (4294549) | 4294549..4294770 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| P8621_RS20975 (4295035) | 4295035..4295910 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| P8621_RS20980 (4295907) | 4295907..4296194 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| P8621_RS20985 (4296217) | 4296217..4296432 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| P8621_RS20990 (4296440) | 4296440..4296709 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| P8621_RS20995 (4297003) | 4297003..4297908 | - | 906 | Protein_4100 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T276154 WP_000626099.1 NZ_CP121262:c4293942-4293451 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT276154 WP_001110452.1 NZ_CP121262:c4294232-4293939 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |