Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4164596..4165112 Replicon chromosome
Accession NZ_CP121262
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag P8621_RS20290 Protein ID WP_000220578.1
Coordinates 4164596..4164880 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P8621_RS20295 Protein ID WP_000212724.1
Coordinates 4164870..4165112 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8621_RS20275 (4159808) 4159808..4161460 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
P8621_RS20280 (4161869) 4161869..4164007 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P8621_RS20285 (4164128) 4164128..4164592 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P8621_RS20290 (4164596) 4164596..4164880 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8621_RS20295 (4164870) 4164870..4165112 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P8621_RS20300 (4165190) 4165190..4167103 - 1914 WP_001212137.1 BglG family transcription antiterminator -
P8621_RS20305 (4167120) 4167120..4167860 - 741 WP_000779263.1 KDGP aldolase family protein -
P8621_RS20310 (4167857) 4167857..4168975 - 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P8621_RS20315 (4168959) 4168959..4170092 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T276153 WP_000220578.1 NZ_CP121262:c4164880-4164596 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT276153 WP_000212724.1 NZ_CP121262:c4165112-4164870 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References