Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3470459..3471079 Replicon chromosome
Accession NZ_CP121262
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P8621_RS17140 Protein ID WP_001280991.1
Coordinates 3470861..3471079 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P8621_RS17135 Protein ID WP_000344807.1
Coordinates 3470459..3470833 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8621_RS17125 (3465598) 3465598..3466791 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P8621_RS17130 (3466814) 3466814..3469963 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P8621_RS17135 (3470459) 3470459..3470833 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P8621_RS17140 (3470861) 3470861..3471079 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P8621_RS17145 (3471258) 3471258..3471809 + 552 WP_001278792.1 maltose O-acetyltransferase -
P8621_RS17150 (3471926) 3471926..3472396 + 471 WP_000136181.1 YlaC family protein -
P8621_RS17155 (3472452) 3472452..3472592 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P8621_RS17160 (3472598) 3472598..3472858 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P8621_RS17165 (3473083) 3473083..3474633 + 1551 WP_000213139.1 EAL domain-containing protein -
P8621_RS17175 (3474864) 3474864..3475253 + 390 WP_000961285.1 MGMT family protein -
P8621_RS17180 (3475286) 3475286..3475855 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T276149 WP_001280991.1 NZ_CP121262:3470861-3471079 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT276149 WP_000344807.1 NZ_CP121262:3470459-3470833 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References