Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206526..207286 Replicon chromosome
Accession NZ_CP121262
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 013

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag P8621_RS00970 Protein ID WP_000533909.1
Coordinates 206801..207286 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag P8621_RS00965 Protein ID WP_000965886.1
Coordinates 206526..206813 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8621_RS00940 (201821) 201821..202123 + 303 WP_000605590.1 YsaB family lipoprotein -
P8621_RS00945 (202262) 202262..203173 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
P8621_RS00950 (203183) 203183..205252 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
P8621_RS00955 (205434) 205434..205709 + 276 Protein_189 IS3 family transposase -
P8621_RS00960 (205881) 205881..206348 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
P8621_RS00965 (206526) 206526..206813 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
P8621_RS00970 (206801) 206801..207286 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
P8621_RS00975 (207658) 207658..208197 - 540 WP_080247774.1 copper-binding periplasmic metallochaperone CueP -
P8621_RS00980 (208371) 208371..208583 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P8621_RS00985 (208872) 208872..209162 - 291 WP_000455790.1 HTH-type transcriptional regulator -
P8621_RS00990 (209601) 209601..210311 + 711 WP_000190524.1 DUF3053 domain-containing protein -
P8621_RS00995 (210361) 210361..211335 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
P8621_RS01000 (211554) 211554..212216 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T276138 WP_000533909.1 NZ_CP121262:206801-207286 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT276138 WP_000965886.1 NZ_CP121262:206526-206813 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References