Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5834509..5835133 Replicon chromosome
Accession NZ_CP121261
Organism Achromobacter spanius strain LIG8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag P8T11_RS26140 Protein ID WP_268079350.1
Coordinates 5834951..5835133 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P8T11_RS26135 Protein ID WP_268079351.1
Coordinates 5834509..5834901 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T11_RS26115 (P8T11_26115) 5829998..5831452 - 1455 WP_268079354.1 sensor histidine kinase -
P8T11_RS26120 (P8T11_26120) 5831456..5832160 - 705 WP_268079353.1 response regulator transcription factor -
P8T11_RS26125 (P8T11_26125) 5832350..5833690 + 1341 WP_277549605.1 CitMHS family transporter -
P8T11_RS26130 (P8T11_26130) 5833728..5834468 + 741 WP_268079352.1 SDR family oxidoreductase -
P8T11_RS26135 (P8T11_26135) 5834509..5834901 - 393 WP_268079351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P8T11_RS26140 (P8T11_26140) 5834951..5835133 - 183 WP_268079350.1 type II toxin-antitoxin system HicA family toxin Toxin
P8T11_RS26145 (P8T11_26145) 5835302..5835643 + 342 WP_268079349.1 hypothetical protein -
P8T11_RS26150 (P8T11_26150) 5835662..5836099 - 438 WP_268079348.1 hypothetical protein -
P8T11_RS26155 (P8T11_26155) 5836563..5836766 + 204 WP_050448526.1 cold-shock protein -
P8T11_RS26160 (P8T11_26160) 5836835..5837092 + 258 WP_259251979.1 hypothetical protein -
P8T11_RS26165 (P8T11_26165) 5837285..5838202 + 918 WP_268079347.1 DUF808 domain-containing protein -
P8T11_RS26170 (P8T11_26170) 5838453..5839322 + 870 WP_268079346.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5788251..6043241 254990


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6765.99 Da        Isoelectric Point: 12.1585

>T276137 WP_268079350.1 NZ_CP121261:c5835133-5834951 [Achromobacter spanius]
MNSREIIRQLRQAGWVFRHAKGSHHIFVHPQKPGHISVPHPKKDLGIGLVTKLLTQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13915.77 Da        Isoelectric Point: 4.2687

>AT276137 WP_268079351.1 NZ_CP121261:c5834901-5834509 [Achromobacter spanius]
MKYPIAIEPGSETQAWGVVVPDLPGCFSAADSGIDEAIENAKEAIELWIETALDSGTPVPVATSIAGHQANPEFAGWIWA
IVEIDPAVMDDTIERINITLPRRILARIDAKARAAGESRSGYIAHLALTH

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References