Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4693357..4694974 Replicon chromosome
Accession NZ_CP121261
Organism Achromobacter spanius strain LIG8

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P8T11_RS21045 Protein ID WP_268080213.1
Coordinates 4693661..4694974 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag P8T11_RS21040 Protein ID WP_268080214.1
Coordinates 4693357..4693617 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8T11_RS21010 (P8T11_21010) 4688504..4688899 + 396 WP_268080220.1 hypothetical protein -
P8T11_RS21015 (P8T11_21015) 4689475..4690155 + 681 WP_268080218.1 hypothetical protein -
P8T11_RS21020 (P8T11_21020) 4690436..4690867 + 432 Protein_4162 integrase core domain-containing protein -
P8T11_RS21025 (P8T11_21025) 4690920..4691426 + 507 WP_268080217.1 PAAR domain-containing protein -
P8T11_RS21030 (P8T11_21030) 4691423..4692064 + 642 WP_268080216.1 VRR-NUC domain-containing protein -
P8T11_RS21035 (P8T11_21035) 4692073..4693170 + 1098 WP_268080215.1 DUF3396 domain-containing protein -
P8T11_RS21040 (P8T11_21040) 4693357..4693617 + 261 WP_268080214.1 helix-turn-helix transcriptional regulator Antitoxin
P8T11_RS21045 (P8T11_21045) 4693661..4694974 + 1314 WP_268080213.1 type II toxin-antitoxin system HipA family toxin Toxin
P8T11_RS21050 (P8T11_21050) 4695005..4695496 - 492 WP_268080212.1 hypothetical protein -
P8T11_RS21055 (P8T11_21055) 4695546..4696025 - 480 WP_268080211.1 hypothetical protein -
P8T11_RS21060 (P8T11_21060) 4696150..4697973 - 1824 WP_268080209.1 SLC13 family permease -
P8T11_RS21065 (P8T11_21065) 4697991..4699418 - 1428 WP_268080207.1 basic amino acid/polyamine antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(1-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48540.60 Da        Isoelectric Point: 6.7741

>T276136 WP_268080213.1 NZ_CP121261:4693661-4694974 [Achromobacter spanius]
MNGEFVGTWSVQPHVGEVLQYADAWVASGQGRPLSLSLPFTPGNPPHRGEAVRTYFENLLPDSKEIRERVARRYQAGSTN
AFALLAEVGRDCVGALQVVPGPDAPDGVQEVNAVPMTDAEIAQLLRNTLAPGPLGRNAAEDEDFRISIAGAQEKSAMLWY
DGRWCRPHGATPTTHIFKLPLGLVANMKFDMSDSVENEWLCSEILRAYQMPVARTEPLMFEDMKVLAVERFDRMWWESPE
GKRWLIRLPQEDMCQATATPPHLKYESDGGPGVRQIMKLLATSRAPDRDRRTFFQAQVLFWMLRATDGHAKNFSIFLRQG
GTYELTPLYDVLSAYPVIGKGAKKLSPYDAKMAMAVRSKNPHWVMRDILRRHWIAVGTEHGVVNPDGKGVEHVLDDLVAR
TPGVVKAVRALLPAGFPMHVADCILNGLQEAADHLAG

Download         Length: 1314 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9398.77 Da        Isoelectric Point: 8.8776

>AT276136 WP_268080214.1 NZ_CP121261:4693357-4693617 [Achromobacter spanius]
MTDFTVRTAEQLPALLQGFRKQSGLTQADTAMRLGVSQQALSHLERHADKVSADRLLELLSILGVELVLRKTSESPSPKA
SVGPNW

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References