Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 7411..8012 Replicon plasmid pPLAN223
Accession NZ_CP121259
Organism Lactiplantibacillus plantarum strain SPC-SNU-72-1

Toxin (Protein)


Gene name pemK Uniprot ID Q684P1
Locus tag P6165_RS15875 Protein ID WP_001748110.1
Coordinates 7668..8012 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A806J926
Locus tag P6165_RS15870 Protein ID WP_001748109.1
Coordinates 7411..7674 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6165_RS15850 (P6165_15850) 3544..4047 + 504 WP_278163029.1 DUF536 domain-containing protein -
P6165_RS15855 (P6165_15855) 4752..5129 + 378 WP_003646093.1 YxeA family protein -
P6165_RS15860 (P6165_15860) 6170..6382 - 213 WP_278163030.1 hypothetical protein -
P6165_RS15865 (P6165_15865) 6738..7325 - 588 WP_278163032.1 site-specific integrase -
P6165_RS15870 (P6165_15870) 7411..7674 + 264 WP_001748109.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P6165_RS15875 (P6165_15875) 7668..8012 + 345 WP_001748110.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P6165_RS15880 (P6165_15880) 8131..9462 - 1332 WP_278163043.1 NAD(P)/FAD-dependent oxidoreductase -
P6165_RS15885 (P6165_15885) 9480..9611 - 132 WP_015474697.1 hypothetical protein -
P6165_RS15890 (P6165_15890) 9624..10271 - 648 WP_006844821.1 DsbA family oxidoreductase -
P6165_RS15895 (P6165_15895) 10290..11234 - 945 WP_278163045.1 thioredoxin-disulfide reductase -
P6165_RS15900 (P6165_15900) 11325..11453 - 129 Protein_12 aspartate racemase -
P6165_RS15905 (P6165_15905) 11453..11776 - 324 WP_006844823.1 thioredoxin family protein -
P6165_RS15910 (P6165_15910) 11797..12111 - 315 WP_015474701.1 thioredoxin -
P6165_RS15915 (P6165_15915) 12125..12406 - 282 WP_008855846.1 thioredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..22390 22390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-104)

Antitoxin

Antitoxin PemI-like

(8-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13041.89 Da        Isoelectric Point: 6.4782

>T276132 WP_001748110.1 NZ_CP121259:7668-8012 [Lactiplantibacillus plantarum]
MVSQGDIFYVNFNPSRGHEQMNKRPAIALSNDLVCQTSNMTIVAPISSTKRNFPMYHRLTSSQTVYGKVLLDQTIALDLR
ARHVTDETIVDHVSREELEEIITLYKLLFSIDDK

Download         Length: 345 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10141.47 Da        Isoelectric Point: 5.7117

>AT276132 WP_001748109.1 NZ_CP121259:7411-7674 [Lactiplantibacillus plantarum]
MELIKEQTRLAKWGNSKAARIPSQIIKQLKLDDNQDMTITIENGSIVLTPIKKNPTNIHELFKDWQDDGKRDHELDWGKS
EGNELQW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2K1X3

Antitoxin

Source ID Structure
AlphaFold DB A0A806J926

References