Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1667655..1668267 Replicon chromosome
Accession NZ_CP121250
Organism Streptococcus pyogenes strain 1044

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag P8191_RS08620 Protein ID WP_010922665.1
Coordinates 1667655..1667990 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag P8191_RS08625 Protein ID WP_002988079.1
Coordinates 1667980..1668267 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8191_RS08585 (P8191_08585) 1663033..1663551 + 519 WP_002982682.1 NYN domain-containing protein -
P8191_RS08590 (P8191_08590) 1663648..1664508 + 861 WP_002982687.1 DegV family protein -
P8191_RS08595 (P8191_08595) 1664644..1665150 + 507 WP_002988070.1 hypothetical protein -
P8191_RS08600 (P8191_08600) 1665147..1665353 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
P8191_RS08605 (P8191_08605) 1665571..1666017 + 447 WP_002982710.1 50S ribosomal protein L13 -
P8191_RS08610 (P8191_08610) 1666038..1666430 + 393 WP_002982716.1 30S ribosomal protein S9 -
P8191_RS08615 (P8191_08615) 1666550..1667557 - 1008 Protein_1653 site-specific integrase -
P8191_RS08620 (P8191_08620) 1667655..1667990 - 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8191_RS08625 (P8191_08625) 1667980..1668267 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
P8191_RS08630 (P8191_08630) 1668928..1669701 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
P8191_RS08635 (P8191_08635) 1670148..1670576 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
P8191_RS08640 (P8191_08640) 1670611..1671126 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
P8191_RS08645 (P8191_08645) 1671174..1672103 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
P8191_RS08650 (P8191_08650) 1672107..1673090 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T276131 WP_010922665.1 NZ_CP121250:c1667990-1667655 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT276131 WP_002988079.1 NZ_CP121250:c1668267-1667980 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References