Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 715881..716434 Replicon chromosome
Accession NZ_CP121247
Organism Arcanobacterium wilhelmae strain DSM 102162

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag P8A24_RS03135 Protein ID WP_278059644.1
Coordinates 716132..716434 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag P8A24_RS03130 Protein ID WP_278059642.1
Coordinates 715881..716126 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8A24_RS03105 (P8A24_03105) 710971..712233 - 1263 WP_278059636.1 MFS transporter -
P8A24_RS03110 (P8A24_03110) 712325..713329 - 1005 Protein_604 DUF5692 family protein -
P8A24_RS03115 (P8A24_03115) 713327..713668 + 342 Protein_605 hypothetical protein -
P8A24_RS03120 (P8A24_03120) 713756..714748 + 993 WP_278059638.1 DUF5692 family protein -
P8A24_RS03125 (P8A24_03125) 714806..715780 - 975 WP_278059639.1 EamA family transporter -
P8A24_RS03130 (P8A24_03130) 715881..716126 + 246 WP_278059642.1 YlcI/YnfO family protein Antitoxin
P8A24_RS03135 (P8A24_03135) 716132..716434 + 303 WP_278059644.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P8A24_RS03140 (P8A24_03140) 716676..717098 + 423 WP_278059646.1 DUF2871 family protein -
P8A24_RS03145 (P8A24_03145) 717205..718173 + 969 WP_278059648.1 pirin family protein -
P8A24_RS03150 (P8A24_03150) 718333..719472 + 1140 WP_278059650.1 L-lactate dehydrogenase -
P8A24_RS03155 (P8A24_03155) 719611..721014 - 1404 WP_278059652.1 argininosuccinate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11179.10 Da        Isoelectric Point: 8.0184

>T276129 WP_278059644.1 NZ_CP121247:716132-716434 [Arcanobacterium wilhelmae]
MREIRLAKLDKTRPVLILTREIALPAMRKVTVAPITSTIRGLTSEVRVGQRNGLDHECVVALDNITTIPQTLLGKRIGYF
FDEQESELSLGLSLAFDLPF

Download         Length: 303 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9079.13 Da        Isoelectric Point: 4.4734

>AT276129 WP_278059642.1 NZ_CP121247:715881-716126 [Arcanobacterium wilhelmae]
MTVQIAVRIPDELAEFIDAEVHKGGARNRTDFVTSAIERDMRRRLAMRDAQILREQGAEDDLDSLVAWSAGRSSSVFSDL
D

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References