Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 75676..76329 Replicon chromosome
Accession NZ_CP121233
Organism Enterococcus faecalis strain SVJ-EF01

Toxin (Protein)


Gene name hicA Uniprot ID R3IHS7
Locus tag ORD27_RS00325 Protein ID WP_002367585.1
Coordinates 76147..76329 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID R3IHD2
Locus tag ORD27_RS00320 Protein ID WP_010707936.1
Coordinates 75676..76113 (-) Length 146 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORD27_RS00305 (70952) 70952..71650 + 699 WP_010707934.1 N-acetylmannosamine-6-phosphate 2-epimerase -
ORD27_RS00310 (71828) 71828..74167 + 2340 WP_071646506.1 alpha-glucosidase -
ORD27_RS00315 (74714) 74714..75631 + 918 WP_010713649.1 helix-turn-helix transcriptional regulator -
ORD27_RS00320 (75676) 75676..76113 - 438 WP_010707936.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ORD27_RS00325 (76147) 76147..76329 - 183 WP_002367585.1 type II toxin-antitoxin system HicA family toxin Toxin
ORD27_RS00330 (76434) 76434..77087 - 654 WP_002356081.1 Crp/Fnr family transcriptional regulator -
ORD27_RS00335 (77361) 77361..78254 + 894 WP_010775474.1 SDR family oxidoreductase -
ORD27_RS00340 (78267) 78267..78839 + 573 WP_071646507.1 alkaline shock response membrane anchor protein AmaP -
ORD27_RS00345 (78852) 78852..79043 + 192 WP_002356087.1 DUF2273 domain-containing protein -
ORD27_RS00350 (79056) 79056..79568 + 513 WP_002383483.1 Asp23/Gls24 family envelope stress response protein -
ORD27_RS00355 (79627) 79627..80187 + 561 WP_002356090.1 Asp23/Gls24 family envelope stress response protein -
ORD27_RS00360 (80211) 80211..80453 + 243 WP_002356092.1 GlsB/YeaQ/YmgE family stress response membrane protein -
ORD27_RS00365 (80619) 80619..81134 + 516 WP_071646508.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6633.06 Da        Isoelectric Point: 10.8756

>T276106 WP_002367585.1 NZ_CP121233:c76329-76147 [Enterococcus faecalis]
MPMTQKQMVKLLKKHGWLPTDGGKGSHIKMEMSGKRPIIIPHGELKKGTEIGILKEAGLK

Download         Length: 183 bp


Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16267.27 Da        Isoelectric Point: 4.2758

>AT276106 WP_010707936.1 NZ_CP121233:c76113-75676 [Enterococcus faecalis]
MLISYPACFYSVENGYYVYFPDIGGSGTQGDTIPDAIAMASDYLGMMLSDDIEHQRTIHQPSPINTLSLEDNNPFRDDDD
FNFNLADSFVSMVNVELNDYLGTNTLVKKTVTIPKWSDELGKKNKLNFSKTLTDAIVEKSLHVLK

Download         Length: 438 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB R3IHS7


Antitoxin

Source ID Structure
AlphaFold DB R3IHD2

References