276091

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 748667..749321 Replicon chromosome
Accession NZ_CP121223
Organism Shigella flexneri 2a strain Sflex 21-42

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag P5F89_RS05665 Protein ID WP_000244767.1
Coordinates 748667..749074 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D2A730
Locus tag P5F89_RS05670 Protein ID WP_000354052.1
Coordinates 749055..749321 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5F89_RS05645 (744624) 744624..746357 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
P5F89_RS05650 (746363) 746363..747073 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P5F89_RS05655 (747098) 747098..747994 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
P5F89_RS05660 (748106) 748106..748627 + 522 WP_001055867.1 flavodoxin FldB -
P5F89_RS05665 (748667) 748667..749074 - 408 WP_000244767.1 protein YgfX Toxin
P5F89_RS05670 (749055) 749055..749321 - 267 WP_000354052.1 FAD assembly factor SdhE Antitoxin
P5F89_RS05675 (749564) 749564..750544 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
P5F89_RS05680 (750740) 750740..751399 - 660 WP_000250274.1 hemolysin III family protein -
P5F89_RS05685 (751563) 751563..751873 - 311 Protein_704 N(4)-acetylcytidine aminohydrolase -
P5F89_RS05690 (751918) 751918..753351 + 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
P5F89_RS05695 (753408) 753408..754151 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T276091 WP_000244767.1 NZ_CP121223:c749074-748667 [Shigella flexneri 2a]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.05 Da        Isoelectric Point: 5.1599

>AT276091 WP_000354052.1 NZ_CP121223:c749321-749055 [Shigella flexneri 2a]
MDINNKARIHWACRRGMRELDISIMSFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB D2A730

References