Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2258196..2258710 Replicon chromosome
Accession NZ_CP121204
Organism Staphylococcus aureus strain SA0907

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag P7F77_RS11400 Protein ID WP_000581795.1
Coordinates 2258196..2258405 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag P7F77_RS11405 Protein ID WP_000138930.1
Coordinates 2258417..2258710 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7F77_RS11380 (2253704) 2253704..2255062 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
P7F77_RS11385 (2255077) 2255077..2256147 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
P7F77_RS11390 (2256465) 2256465..2257667 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
P7F77_RS11395 (2257931) 2257931..2258068 - 138 WP_000828354.1 Lmo0850 family protein -
P7F77_RS11400 (2258196) 2258196..2258405 - 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
P7F77_RS11405 (2258417) 2258417..2258710 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
P7F77_RS11410 (2258876) 2258876..2260360 + 1485 WP_278043658.1 cardiolipin synthase -
P7F77_RS11415 (2260388) 2260388..2261035 + 648 WP_001187623.1 HD domain-containing protein -
P7F77_RS11420 (2261782) 2261782..2262654 - 873 WP_000725802.1 membrane protein insertase YidC -
P7F77_RS11425 (2262740) 2262740..2263381 - 642 WP_223671414.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T276077 WP_000581795.1 NZ_CP121204:c2258405-2258196 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT276077 WP_000138930.1 NZ_CP121204:c2258710-2258417 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References