Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2238453..2238982 Replicon chromosome
Accession NZ_CP121204
Organism Staphylococcus aureus strain SA0907

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag P7F77_RS11310 Protein ID WP_000621175.1
Coordinates 2238453..2238815 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag P7F77_RS11315 Protein ID WP_000948331.1
Coordinates 2238812..2238982 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7F77_RS11290 (2235431) 2235431..2236201 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
P7F77_RS11295 (2236176) 2236176..2236655 - 480 WP_001190825.1 anti-sigma B factor RsbW -
P7F77_RS11300 (2236657) 2236657..2236983 - 327 WP_001052491.1 anti-sigma factor antagonist -
P7F77_RS11305 (2237102) 2237102..2238103 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
P7F77_RS11310 (2238453) 2238453..2238815 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P7F77_RS11315 (2238812) 2238812..2238982 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
P7F77_RS11320 (2239067) 2239067..2240215 - 1149 WP_001281140.1 alanine racemase -
P7F77_RS11325 (2240281) 2240281..2240640 - 360 WP_000581197.1 holo-ACP synthase -
P7F77_RS11330 (2240644) 2240644..2241135 - 492 WP_001205908.1 PH domain-containing protein -
P7F77_RS11335 (2241122) 2241122..2242705 - 1584 WP_001294637.1 PH domain-containing protein -
P7F77_RS11340 (2242698) 2242698..2243177 - 480 WP_001287077.1 hypothetical protein -
P7F77_RS11345 (2243385) 2243385..2243945 - 561 WP_001092406.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T276076 WP_000621175.1 NZ_CP121204:c2238815-2238453 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT276076 WP_000948331.1 NZ_CP121204:c2238982-2238812 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References