276075

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2158657..2159134 Replicon chromosome
Accession NZ_CP121204
Organism Staphylococcus aureus strain SA0907

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag P7F77_RS10875 Protein ID WP_000052076.1
Coordinates 2158946..2159134 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag P7F77_RS10870 Protein ID WP_001059690.1
Coordinates 2158657..2158917 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7F77_RS10835 (2154026) 2154026..2154742 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
P7F77_RS10840 (2154890) 2154890..2155312 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
P7F77_RS10845 (2155711) 2155711..2156205 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
P7F77_RS10850 (2156361) 2156361..2156978 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
P7F77_RS10855 (2157075) 2157075..2157656 - 582 WP_001140696.1 histidine phosphatase family protein -
P7F77_RS10860 (2157880) 2157880..2158116 + 237 WP_000368687.1 hypothetical protein -
P7F77_RS10865 (2158113) 2158113..2158316 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
P7F77_RS10870 (2158657) 2158657..2158917 + 261 WP_001059690.1 hypothetical protein Antitoxin
P7F77_RS10875 (2158946) 2158946..2159134 + 189 WP_000052076.1 hypothetical protein Toxin
P7F77_RS10880 (2159322) 2159322..2159891 + 570 WP_001106662.1 lipoprotein N-acylation protein LnsA -
P7F77_RS10885 (2159979) 2159979..2160251 + 273 WP_001004400.1 hypothetical protein -
P7F77_RS10890 (2160324) 2160324..2160542 + 219 WP_000005884.1 hypothetical protein -
P7F77_RS10895 (2161038) 2161038..2161238 - 201 WP_001059082.1 cold-shock protein -
P7F77_RS10900 (2161595) 2161595..2162281 - 687 WP_001812985.1 thermonuclease family protein -
P7F77_RS10905 (2162622) 2162622..2163167 - 546 WP_000824465.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T276075 WP_000052076.1 NZ_CP121204:2158946-2159134 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT276075 WP_001059690.1 NZ_CP121204:2158657-2158917 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References