Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2001210..2001986 Replicon chromosome
Accession NZ_CP121204
Organism Staphylococcus aureus strain SA0907

Toxin (Protein)


Gene name tsbT Uniprot ID A0A0U1MPP1
Locus tag P7F77_RS09770 Protein ID WP_000031104.1
Coordinates 2001210..2001362 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag P7F77_RS09775 Protein ID WP_001251224.1
Coordinates 2001387..2001986 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7F77_RS09755 (1997129) 1997129..1997950 + 822 WP_031875108.1 RluA family pseudouridine synthase -
P7F77_RS09760 (1998407) 1998407..1999792 - 1386 WP_000116238.1 class II fumarate hydratase -
P7F77_RS09765 (1999988) 1999988..2000383 - 396 WP_000901020.1 hypothetical protein -
P7F77_RS09770 (2001210) 2001210..2001362 - 153 WP_000031104.1 SAS053 family protein Toxin
P7F77_RS09775 (2001387) 2001387..2001986 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
P7F77_RS09780 (2002145) 2002145..2002615 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
P7F77_RS09785 (2002620) 2002620..2003747 - 1128 WP_000379991.1 tRNA epoxyqueuosine(34) reductase QueG -
P7F77_RS09790 (2003898) 2003898..2004620 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
P7F77_RS09795 (2004613) 2004613..2006070 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5963.31 Da        Isoelectric Point: 3.9075

>T276071 WP_000031104.1 NZ_CP121204:c2001362-2001210 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVNDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT276071 WP_001251224.1 NZ_CP121204:c2001986-2001387 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MPP1

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References