276062

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 879637..880166 Replicon chromosome
Accession NZ_CP121204
Organism Staphylococcus aureus strain SA0907

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag P7F77_RS04195 Protein ID WP_001103933.1
Coordinates 879849..880166 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag P7F77_RS04190 Protein ID WP_001058487.1
Coordinates 879637..879846 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7F77_RS04155 (876088) 876088..876552 + 465 WP_001085185.1 SsrA-binding protein SmpB -
P7F77_RS04165 (877115) 877115..878221 - 1107 WP_000121223.1 tyrosine-type recombinase/integrase -
P7F77_RS04170 (878227) 878227..878844 - 618 WP_223200480.1 helix-turn-helix transcriptional regulator -
P7F77_RS04175 (879032) 879032..879238 + 207 WP_001060953.1 hypothetical protein -
P7F77_RS04180 (879274) 879274..879501 + 228 WP_000164237.1 helix-turn-helix transcriptional regulator -
P7F77_RS04185 (879498) 879498..879644 + 147 WP_000784893.1 hypothetical protein -
P7F77_RS04190 (879637) 879637..879846 + 210 WP_001058487.1 hypothetical protein Antitoxin
P7F77_RS04195 (879849) 879849..880166 + 318 WP_001103933.1 DUF1474 family protein Toxin
P7F77_RS04200 (880233) 880233..881102 + 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
P7F77_RS04205 (881119) 881119..882588 + 1470 WP_001668899.1 virulence-associated E family protein -
P7F77_RS04210 (882874) 882874..883236 + 363 WP_001039169.1 hypothetical protein -
P7F77_RS04215 (883238) 883238..883522 + 285 WP_000998179.1 hypothetical protein -
P7F77_RS04220 (883519) 883519..884160 + 642 WP_063663413.1 pathogenicity island protein -
P7F77_RS04225 (884610) 884610..884951 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlb 877115..941748 64633


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T276062 WP_001103933.1 NZ_CP121204:879849-880166 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT276062 WP_001058487.1 NZ_CP121204:879637-879846 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References