276061

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 796780..797888 Replicon chromosome
Accession NZ_CP121201
Organism Streptococcus pluranimalium strain SP28

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag P7F70_RS04100 Protein ID WP_000233000.1
Coordinates 797019..797888 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag P7F70_RS04095 Protein ID WP_000205227.1
Coordinates 796780..797004 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7F70_RS04075 (P7F70_04075) 792411..793895 + 1485 WP_278025183.1 ABC-F type ribosomal protection protein Lsa(E) -
P7F70_RS04080 (P7F70_04080) 793949..794752 + 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
P7F70_RS04085 (P7F70_04085) 795061..796362 - 1302 Protein_751 ISL3 family transposase -
P7F70_RS04090 (P7F70_04090) 796551..796637 + 87 Protein_752 site-specific recombinase -
P7F70_RS04095 (P7F70_04095) 796780..797004 + 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
P7F70_RS04100 (P7F70_04100) 797019..797888 + 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
P7F70_RS04105 (P7F70_04105) 797869..798603 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
P7F70_RS04110 (P7F70_04110) 798636..799499 + 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
P7F70_RS04115 (P7F70_04115) 799543..800043 + 501 WP_105141283.1 phosphoribosyltransferase family protein -
P7F70_RS04120 (P7F70_04120) 800129..801303 + 1175 Protein_758 IS256-like element IS256 family transposase -
P7F70_RS04125 (P7F70_04125) 801360..801752 + 393 WP_000393259.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O/W/32/O) / erm(B) / dfrG / ant(6)-Ia / lsa(E) / lnu(B) / aac(6')-aph(2'') / tet(L) / cat - 702088..827611 125523
- inside IScluster/Tn dfrG / ant(6)-Ia / lsa(E) / lnu(B) / aac(6')-aph(2'') / tet(L) / cat - 785323..813297 27974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T276061 WP_000233000.1 NZ_CP121201:797019-797888 [Streptococcus pluranimalium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT276061 WP_000205227.1 NZ_CP121201:796780-797004 [Streptococcus pluranimalium]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References