276060

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 780901..782038 Replicon chromosome
Accession NZ_CP121201
Organism Streptococcus pluranimalium strain SP28

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag P7F70_RS04010 Protein ID WP_278025181.1
Coordinates 781175..782038 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag P7F70_RS04005 Protein ID WP_000301765.1
Coordinates 780901..781173 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7F70_RS03965 (P7F70_03965) 775947..776138 + 192 WP_000503424.1 hypothetical protein -
P7F70_RS03970 (P7F70_03970) 776192..777292 + 1101 Protein_728 recombinase family protein -
P7F70_RS03975 (P7F70_03975) 777442..778182 + 741 WP_230340808.1 hypothetical protein -
P7F70_RS03980 (P7F70_03980) 778203..778286 + 84 WP_018451764.1 23S rRNA methyltransferase attenuation leader peptide -
P7F70_RS03985 (P7F70_03985) 778411..779148 + 738 WP_002321849.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
P7F70_RS03990 (P7F70_03990) 779318..779578 + 261 Protein_732 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
P7F70_RS03995 (P7F70_03995) 779681..780577 + 897 WP_001809760.1 ParA family protein -
P7F70_RS04000 (P7F70_04000) 780669..780884 + 216 WP_002321610.1 peptide-binding protein -
P7F70_RS04005 (P7F70_04005) 780901..781173 + 273 WP_000301765.1 antitoxin Antitoxin
P7F70_RS04010 (P7F70_04010) 781175..782038 + 864 WP_278025181.1 zeta toxin family protein Toxin
P7F70_RS04015 (P7F70_04015) 782479..782796 + 318 WP_002338433.1 hypothetical protein -
P7F70_RS04020 (P7F70_04020) 783008..783292 + 285 WP_000922261.1 hypothetical protein -
P7F70_RS04025 (P7F70_04025) 783299..785251 + 1953 WP_000163792.1 hypothetical protein -
P7F70_RS04030 (P7F70_04030) 785323..785820 - 498 WP_000868795.1 trimethoprim-resistant dihydrofolate reductase DfrG -
P7F70_RS04035 (P7F70_04035) 786009..786689 - 681 WP_278025182.1 IS6-like element IS1216 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O/W/32/O) / erm(B) / dfrG / ant(6)-Ia / lsa(E) / lnu(B) / aac(6')-aph(2'') / tet(L) / cat - 702088..827611 125523
- inside IScluster/Tn dfrG / ant(6)-Ia / lsa(E) / lnu(B) / aac(6')-aph(2'') / tet(L) / cat - 785323..813297 27974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32343.84 Da        Isoelectric Point: 6.6610

>T276060 WP_278025181.1 NZ_CP121201:781175-782038 [Streptococcus pluranimalium]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGSVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT276060 WP_000301765.1 NZ_CP121201:780901-781173 [Streptococcus pluranimalium]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References