Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 753765..755197 Replicon chromosome
Accession NZ_CP121201
Organism Streptococcus pluranimalium strain SP28

Toxin (Protein)


Gene name abiEi Uniprot ID G7SFZ4
Locus tag P7F70_RS03885 Protein ID WP_001030299.1
Coordinates 753765..754610 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID G7SFZ3
Locus tag P7F70_RS03890 Protein ID WP_000037237.1
Coordinates 754607..755197 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7F70_RS03875 (P7F70_03875) 750018..750899 + 882 Protein_709 type IV secretion system protein VirB4 -
P7F70_RS03880 (P7F70_03880) 750901..753702 + 2802 WP_278025177.1 phage tail tip lysozyme -
P7F70_RS03885 (P7F70_03885) 753765..754610 - 846 WP_001030299.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
P7F70_RS03890 (P7F70_03890) 754607..755197 - 591 WP_000037237.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O/W/32/O) / erm(B) / dfrG / ant(6)-Ia / lsa(E) / lnu(B) / aac(6')-aph(2'') / tet(L) / cat - 702088..827611 125523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32462.14 Da        Isoelectric Point: 5.4404

>T276059 WP_001030299.1 NZ_CP121201:c754610-753765 [Streptococcus pluranimalium]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23056.59 Da        Isoelectric Point: 7.8056

>AT276059 WP_000037237.1 NZ_CP121201:c755197-754607 [Streptococcus pluranimalium]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPLGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SFZ4

Antitoxin

Source ID Structure
AlphaFold DB G7SFZ3

References