Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4286011..4286606 Replicon chromosome
Accession NZ_CP121199
Organism Escherichia coli strain E50

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag P6H83_RS20740 Protein ID WP_000239581.1
Coordinates 4286011..4286361 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag P6H83_RS20745 Protein ID WP_001223213.1
Coordinates 4286355..4286606 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H83_RS20720 (4281465) 4281465..4282487 - 1023 WP_001361374.1 ABC transporter permease -
P6H83_RS20725 (4282501) 4282501..4284003 - 1503 WP_001095661.1 ATP-binding cassette domain-containing protein -
P6H83_RS20730 (4284136) 4284136..4285092 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
P6H83_RS20735 (4285402) 4285402..4285932 + 531 WP_000055072.1 inorganic diphosphatase -
P6H83_RS20740 (4286011) 4286011..4286361 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
P6H83_RS20745 (4286355) 4286355..4286606 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
P6H83_RS20750 (4286818) 4286818..4287159 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
P6H83_RS20755 (4287162) 4287162..4290941 - 3780 WP_000060873.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T276053 WP_000239581.1 NZ_CP121199:c4286361-4286011 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT276053 WP_001223213.1 NZ_CP121199:c4286606-4286355 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References