Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4329217..4329733 Replicon chromosome
Accession NZ_CP121189
Organism Salmonella enterica subsp. enterica serovar Indiana strain S1467

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag P6164_RS21125 Protein ID WP_000220577.1
Coordinates 4329217..4329501 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P6164_RS21130 Protein ID WP_000212724.1
Coordinates 4329491..4329733 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6164_RS21110 (4324333) 4324333..4325985 + 1653 WP_000155050.1 alpha,alpha-phosphotrehalase -
P6164_RS21115 (4326394) 4326394..4328532 + 2139 WP_023226981.1 anaerobic ribonucleoside-triphosphate reductase -
P6164_RS21120 (4328749) 4328749..4329213 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P6164_RS21125 (4329217) 4329217..4329501 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P6164_RS21130 (4329491) 4329491..4329733 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P6164_RS21135 (4329811) 4329811..4331724 - 1914 WP_023226980.1 BglG family transcription antiterminator -
P6164_RS21140 (4331741) 4331741..4332481 - 741 WP_000779254.1 KDGP aldolase family protein -
P6164_RS21145 (4332478) 4332478..4333596 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P6164_RS21150 (4333580) 4333580..4334713 - 1134 WP_023226979.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T276026 WP_000220577.1 NZ_CP121189:c4329501-4329217 [Salmonella enterica subsp. enterica serovar Indiana]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT276026 WP_000212724.1 NZ_CP121189:c4329733-4329491 [Salmonella enterica subsp. enterica serovar Indiana]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References