Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3597308..3597928 Replicon chromosome
Accession NZ_CP121189
Organism Salmonella enterica subsp. enterica serovar Indiana strain S1467

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P6164_RS17640 Protein ID WP_001280991.1
Coordinates 3597710..3597928 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P6164_RS17635 Protein ID WP_000344807.1
Coordinates 3597308..3597682 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6164_RS17625 (3592447) 3592447..3593640 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P6164_RS17630 (3593663) 3593663..3596812 + 3150 WP_051129102.1 efflux RND transporter permease AcrB -
P6164_RS17635 (3597308) 3597308..3597682 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P6164_RS17640 (3597710) 3597710..3597928 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P6164_RS17645 (3598107) 3598107..3598658 + 552 WP_001278793.1 maltose O-acetyltransferase -
P6164_RS17650 (3598776) 3598776..3599246 + 471 WP_000136181.1 YlaC family protein -
P6164_RS17655 (3599302) 3599302..3599442 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P6164_RS17660 (3599448) 3599448..3599708 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P6164_RS17665 (3599933) 3599933..3601483 + 1551 WP_023210786.1 EAL domain-containing protein -
P6164_RS17675 (3601714) 3601714..3602103 + 390 WP_000961285.1 MGMT family protein -
P6164_RS17680 (3602136) 3602136..3602705 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T276023 WP_001280991.1 NZ_CP121189:3597710-3597928 [Salmonella enterica subsp. enterica serovar Indiana]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT276023 WP_000344807.1 NZ_CP121189:3597308-3597682 [Salmonella enterica subsp. enterica serovar Indiana]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References