Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2574458..2574980 Replicon chromosome
Accession NZ_CP121189
Organism Salmonella enterica subsp. enterica serovar Indiana strain S1467

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag P6164_RS12560 Protein ID WP_000221343.1
Coordinates 2574696..2574980 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag P6164_RS12555 Protein ID WP_000885424.1
Coordinates 2574458..2574706 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6164_RS12530 (2570100) 2570100..2571566 + 1467 WP_023893409.1 hypothetical protein -
P6164_RS12535 (2571597) 2571597..2571719 - 123 WP_254891910.1 hypothetical protein -
P6164_RS12540 (2572183) 2572183..2572470 + 288 WP_071787797.1 helix-turn-helix domain-containing protein -
P6164_RS12545 (2572542) 2572542..2573450 - 909 WP_077910000.1 hypothetical protein -
P6164_RS12550 (2573601) 2573601..2573933 - 333 WP_023227504.1 DUF1493 family protein -
P6164_RS12555 (2574458) 2574458..2574706 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P6164_RS12560 (2574696) 2574696..2574980 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P6164_RS12565 (2575028) 2575028..2575228 + 201 Protein_2462 Rid family hydrolase -
P6164_RS12570 (2575280) 2575280..2576359 - 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
P6164_RS12575 (2576552) 2576552..2577040 - 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
P6164_RS12580 (2577085) 2577085..2578593 + 1509 WP_023227500.1 FAD-dependent oxidoreductase -
P6164_RS12585 (2578583) 2578583..2579824 + 1242 WP_023227499.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2571615..2581450 9835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T276021 WP_000221343.1 NZ_CP121189:2574696-2574980 [Salmonella enterica subsp. enterica serovar Indiana]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT276021 WP_000885424.1 NZ_CP121189:2574458-2574706 [Salmonella enterica subsp. enterica serovar Indiana]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References