Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 943730..944355 Replicon chromosome
Accession NZ_CP121189
Organism Salmonella enterica subsp. enterica serovar Indiana strain S1467

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P6164_RS04635 Protein ID WP_000911337.1
Coordinates 943957..944355 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag P6164_RS04630 Protein ID WP_000557545.1
Coordinates 943730..943957 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6164_RS04600 (938775) 938775..940292 + 1518 WP_000003339.1 lysine--tRNA ligase -
P6164_RS04605 (940368) 940368..940913 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
P6164_RS04610 (941178) 941178..941936 + 759 WP_000244318.1 amidase activator ActS -
P6164_RS04620 (942221) 942221..943027 - 807 WP_010989071.1 DUF1460 domain-containing protein -
P6164_RS04625 (943302) 943302..943562 - 261 WP_023227725.1 hypothetical protein -
P6164_RS04630 (943730) 943730..943957 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
P6164_RS04635 (943957) 943957..944355 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
P6164_RS04640 (945159) 945159..945695 + 537 WP_023227726.1 STM3031 family outer membrane protein -
P6164_RS04645 (945742) 945742..946374 + 633 WP_023227727.1 YfdX family protein -
P6164_RS04650 (947093) 947093..947680 + 588 WP_023227728.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 942221..953548 11327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T276015 WP_000911337.1 NZ_CP121189:943957-944355 [Salmonella enterica subsp. enterica serovar Indiana]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT276015 WP_000557545.1 NZ_CP121189:943730-943957 [Salmonella enterica subsp. enterica serovar Indiana]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References