276011

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1138124..1139232 Replicon chromosome
Accession NZ_CP121160
Organism Streptococcus agalactiae strain S5

Toxin (Protein)


Gene name MNTss Uniprot ID -
Locus tag P8R99_RS05865 Protein ID WP_046391877.1
Coordinates 1138124..1138993 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag P8R99_RS05870 Protein ID WP_002303393.1
Coordinates 1139008..1139232 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R99_RS05830 1133126..1133929 - 804 WP_000140980.1 ABC transporter ATP-binding protein -
P8R99_RS05835 1133941..1134762 - 822 WP_017646958.1 ABC transporter permease -
P8R99_RS05840 1134759..1135181 - 423 Protein_1127 ABC transporter permease -
P8R99_RS05845 1135232..1135912 - 681 WP_278043276.1 IS6-like element IS1216 family transposase -
P8R99_RS05850 1135966..1136469 - 504 WP_278043396.1 phosphoribosyltransferase family protein -
P8R99_RS05855 1136513..1137376 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
P8R99_RS05860 1137409..1138143 - 735 WP_010725595.1 class I SAM-dependent methyltransferase -
P8R99_RS05865 1138124..1138993 - 870 WP_046391877.1 nucleotidyltransferase domain-containing protein Toxin
P8R99_RS05870 1139008..1139232 - 225 WP_002303393.1 helix-turn-helix transcriptional regulator Antitoxin
P8R99_RS05875 1139313..1139786 - 474 WP_226316671.1 GrpB family protein -
P8R99_RS05880 1139904..1141367 - 1464 WP_216806948.1 ABC-F type ribosomal protection protein Msr(D) -
P8R99_RS05885 1141487..1142704 - 1218 WP_159373770.1 macrolide efflux MFS transporter Mef(A) -
P8R99_RS05890 1143240..1143874 - 635 Protein_1137 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(6)-Ia / msr(D) / mef(A) / lnu(D) - 1035145..1152937 117792
- inside IS/Tn ant(6)-Ia / msr(D) / mef(A) / lnu(D) - 1135232..1144853 9621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32829.52 Da        Isoelectric Point: 4.8826

>T276011 WP_046391877.1 NZ_CP121160:c1138993-1138124 [Streptococcus agalactiae]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVKEIATEINNFLNEENLNERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT276011 WP_002303393.1 NZ_CP121160:c1139232-1139008 [Streptococcus agalactiae]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5SHM7

References