Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1045305..1045917 Replicon chromosome
Accession NZ_CP121160
Organism Streptococcus agalactiae strain S5

Toxin (Protein)


Gene name parE Uniprot ID Q8E7D3
Locus tag P8R99_RS05360 Protein ID WP_000384859.1
Coordinates 1045582..1045917 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E7D2
Locus tag P8R99_RS05355 Protein ID WP_000259017.1
Coordinates 1045305..1045592 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R99_RS05335 1040378..1042279 + 1902 WP_278043367.1 DUF4013 domain-containing protein -
P8R99_RS05340 1042282..1043385 + 1104 WP_017648212.1 CHAP domain-containing protein -
P8R99_RS05345 1043407..1043673 + 267 WP_017648213.1 helix-turn-helix domain-containing protein -
P8R99_RS05350 1043686..1044903 + 1218 WP_017648214.1 tyrosine-type recombinase/integrase -
P8R99_RS05355 1045305..1045592 + 288 WP_000259017.1 hypothetical protein Antitoxin
P8R99_RS05360 1045582..1045917 + 336 WP_000384859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P8R99_RS05365 1046222..1046692 - 471 WP_000130119.1 hypothetical protein -
P8R99_RS05370 1046860..1048116 - 1257 WP_000122836.1 MobV family relaxase -
P8R99_RS05375 1048433..1048867 - 435 WP_001220479.1 hypothetical protein -
P8R99_RS05380 1048903..1049778 - 876 WP_000421240.1 hypothetical protein -
P8R99_RS05385 1050078..1050719 - 642 WP_000591144.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(6)-Ia / msr(D) / mef(A) / lnu(D) - 1035145..1152937 117792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13296.98 Da        Isoelectric Point: 4.6565

>T276010 WP_000384859.1 NZ_CP121160:1045582-1045917 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.7271

>AT276010 WP_000259017.1 NZ_CP121160:1045305-1045592 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076Z4V6

References