Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 668083..669515 Replicon chromosome
Accession NZ_CP121160
Organism Streptococcus agalactiae strain S5

Toxin (Protein)


Gene name abiEi Uniprot ID A0A4T2H6P3
Locus tag P8R99_RS03335 Protein ID WP_024418035.1
Coordinates 668670..669515 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID -
Locus tag P8R99_RS03330 Protein ID WP_278043350.1
Coordinates 668083..668673 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R99_RS03330 668083..668673 + 591 WP_278043350.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
P8R99_RS03335 668670..669515 + 846 WP_024418035.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
P8R99_RS03340 669577..672378 - 2802 WP_278043351.1 phage tail tip lysozyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) - 618537..682959 64422


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32518.24 Da        Isoelectric Point: 5.2292

>T276009 WP_024418035.1 NZ_CP121160:668670-669515 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQIIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23231.84 Da        Isoelectric Point: 7.8303

>AT276009 WP_278043350.1 NZ_CP121160:668083-668673 [Streptococcus agalactiae]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4T2H6P3

Antitoxin

Source ID Structure

References