Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-couple_hipB |
| Location | 637064..638307 | Replicon | chromosome |
| Accession | NZ_CP121160 | ||
| Organism | Streptococcus agalactiae strain S5 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | G7SEB4 |
| Locus tag | P8R99_RS03190 | Protein ID | WP_001235242.1 |
| Coordinates | 637064..637831 (-) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | P8R99_RS03195 | Protein ID | WP_000578719.1 |
| Coordinates | 637831..638307 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P8R99_RS03175 | 633451..633816 | - | 366 | WP_010730300.1 | MobC family plasmid mobilization relaxosome protein | - |
| P8R99_RS03180 | 633826..634185 | - | 360 | WP_278043348.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| P8R99_RS03185 | 634520..637063 | - | 2544 | WP_000601012.1 | AAA family ATPase | - |
| P8R99_RS03190 | 637064..637831 | - | 768 | WP_001235242.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| P8R99_RS03195 | 637831..638307 | - | 477 | WP_000578719.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| P8R99_RS03200 | 638377..638667 | - | 291 | WP_000667951.1 | hypothetical protein | - |
| P8R99_RS03205 | 638718..639107 | - | 390 | WP_000048066.1 | DUF5945 family protein | - |
| P8R99_RS03210 | 639104..639331 | - | 228 | WP_000110922.1 | DUF5965 family protein | - |
| P8R99_RS03215 | 639359..640459 | - | 1101 | WP_000196860.1 | toprim domain-containing protein | - |
| P8R99_RS03220 | 640523..642379 | - | 1857 | WP_001820670.1 | recombinase family protein | - |
| P8R99_RS03225 | 642434..642697 | - | 264 | WP_000253176.1 | hypothetical protein | - |
| P8R99_RS03230 | 642697..642927 | - | 231 | WP_001206986.1 | PC4/YdbC family ssDNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(O) | - | 618537..682959 | 64422 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 28985.80 Da Isoelectric Point: 5.1126
>T276008 WP_001235242.1 NZ_CP121160:c637831-637064 [Streptococcus agalactiae]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18266.77 Da Isoelectric Point: 4.6424
>AT276008 WP_000578719.1 NZ_CP121160:c638307-637831 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|