Detailed information of TA system TA276007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 1119248..1120500
• Replicon: chromosome
• Accession: NZ_CP121159
• Organism: Streptococcus agalactiae strain S1

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z9JWN4
• Locus tag: P8R98_RS05650
• Protein ID: WP_011922437.1
• Coordinates: 1119724..1120500 (+)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: P8R98_RS05645
• Protein ID: WP_012775115.1
• Coordinates: 1119248..1119724 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P8R98_RS05620	1116418..1117056	+	639	WP_011922443.1	hypothetical protein	-
P8R98_RS05625	1117095..1118171	+	1077	WP_011922442.1	toprim domain-containing protein	-
P8R98_RS05630	1118225..1118452	+	228	WP_011922441.1	DUF5965 family protein	-
P8R98_RS05635	1118449..1118838	+	390	WP_011922440.1	DUF5945 family protein	-
P8R98_RS05640	1118888..1119178	+	291	WP_024379089.1	hypothetical protein	-
P8R98_RS05645	1119248..1119724	+	477	WP_012775115.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
P8R98_RS05650	1119724..1120500	+	777	WP_011922437.1	type II toxin-antitoxin system toxin PezT	Toxin
P8R98_RS05655	1120497..1122584	+	2088	WP_011922436.1	AAA family ATPase	-
P8R98_RS05660	1122571..1124388	+	1818	WP_278043522.1	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	ant(6)-Ia / tet(M)	-	1073875..1174187	100312

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29171.98 Da
• Isoelectric Point: 5.2489

>T276007 WP_011922437.1 NZ_CP121159:1119724-1120500 [Streptococcus agalactiae]
MRLEEFSEAAFQKALQRTIRALIRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDQIQIYQRDRTCIYDSEIDEGSAVEVLQECLFGQWSKVEEEML
KAGQERLGELVSANGEKK

Nucleotide

• Length: 777 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18282.69 Da
• Isoelectric Point: 4.4750

>AT276007 WP_012775115.1 NZ_CP121159:1119248-1119724 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

Structures

Toxin

• AlphaFold DB: A0A0Z9JWN4