Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1108122..1109230 Replicon chromosome
Accession NZ_CP121159
Organism Streptococcus agalactiae strain S1

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag P8R98_RS05585 Protein ID WP_000233000.1
Coordinates 1108122..1108991 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag P8R98_RS05590 Protein ID WP_000205227.1
Coordinates 1109006..1109230 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P8R98_RS05565 1104393..1105712 - 1320 WP_002338419.1 IS1380-like element ISSsu5 family transposase -
P8R98_RS05570 1105940..1106467 - 528 WP_002294507.1 phosphoribosyltransferase family protein -
P8R98_RS05575 1106511..1107374 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
P8R98_RS05580 1107407..1108141 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
P8R98_RS05585 1108122..1108991 - 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
P8R98_RS05590 1109006..1109230 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
P8R98_RS05595 1109373..1110917 - 1545 WP_002390960.1 recombinase family protein -
P8R98_RS05600 1110937..1111353 - 417 WP_000323438.1 recombinase -
P8R98_RS05605 1111354..1111851 - 498 WP_002327635.1 DNA recombinase -
P8R98_RS05610 1112265..1113290 + 1026 WP_278043520.1 lanthionine synthetase LanC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(6)-Ia / tet(M) - 1073875..1174187 100312
- flank IS/Tn ant(6)-Ia - 1104393..1107374 2981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T276006 WP_000233000.1 NZ_CP121159:c1108991-1108122 [Streptococcus agalactiae]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT276006 WP_000205227.1 NZ_CP121159:c1109230-1109006 [Streptococcus agalactiae]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References