Detailed information of TA system TA276005

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1087429..1088861
• Replicon: chromosome
• Accession: NZ_CP121159
• Organism: Streptococcus agalactiae strain S1

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A0Z8VZ26
• Locus tag: P8R98_RS05515
• Protein ID: WP_011922458.1
• Coordinates: 1087429..1088274 (-)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A0Z8YIZ2
• Locus tag: P8R98_RS05520
• Protein ID: WP_011922457.1
• Coordinates: 1088271..1088861 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P8R98_RS05510	1084565..1087366	+	2802	WP_011922459.1	phage tail tip lysozyme	-
P8R98_RS05515	1087429..1088274	-	846	WP_011922458.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
P8R98_RS05520	1088271..1088861	-	591	WP_011922457.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	ant(6)-Ia / tet(M)	-	1073875..1174187	100312

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-259)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32518.29 Da
• Isoelectric Point: 5.2158

>T276005 WP_011922458.1 NZ_CP121159:c1088274-1087429 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETVLDFEKIIELLERFKSDP
IQNQQWQNYSKKYSYTKGISLADVLEEMIRLIAVLISINFD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23151.74 Da
• Isoelectric Point: 7.8272

>AT276005 WP_011922457.1 NZ_CP121159:c1088861-1088271 [Streptococcus agalactiae]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKENSELGITLVKTPMGNEVRVYDFERIICDFVIHREKIDTELFVKT
LQLYGNYPKKNLTKLYEYATKMSTLAKVKQTLEVLV

Nucleotide

• Length: 591 bp

Structures

Toxin

• AlphaFold DB: A0A0Z8VZ26

Antitoxin

• AlphaFold DB: A0A0Z8YIZ2