276003

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 61445..62088 Replicon plasmid pE89-1
Accession NZ_CP121158
Organism Escherichia coli strain E89

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag P6H86_RS23900 Protein ID WP_001034044.1
Coordinates 61672..62088 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag P6H86_RS23895 Protein ID WP_001261286.1
Coordinates 61445..61675 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H86_RS23880 (56582) 56582..56812 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
P6H86_RS23885 (56809) 56809..57225 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
P6H86_RS23890 (57270) 57270..61064 - 3795 WP_001144732.1 hypothetical protein -
P6H86_RS23895 (61445) 61445..61675 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P6H86_RS23900 (61672) 61672..62088 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
P6H86_RS23905 (62163) 62163..63728 + 1566 WP_001128474.1 AAA family ATPase -
P6H86_RS23910 (63713) 63713..64735 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(42) / ant(3'')-Ia / sitABCD / fosA3 / blaTEM-1B / blaCTX-M-55 / aac(3)-IId / mph(A) iutA / iucD / iucC / iucB / iucA 1..159910 159910
- flank IS/Tn - - 64989..65492 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T276003 WP_001034044.1 NZ_CP121158:61672-62088 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT276003 WP_001261286.1 NZ_CP121158:61445-61675 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References