Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4394822..4395747 Replicon chromosome
Accession NZ_CP121157
Organism Escherichia coli strain E89

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag P6H86_RS21740 Protein ID WP_014640052.1
Coordinates 4394822..4395208 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag P6H86_RS21745 Protein ID WP_024174200.1
Coordinates 4395238..4395747 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H86_RS21705 (4389883) 4389883..4390557 + 675 WP_000859461.1 LexA family transcriptional regulator -
P6H86_RS21710 (4391244) 4391244..4391606 + 363 WP_000135680.1 protein YfdP -
P6H86_RS21715 (4391672) 4391672..4392496 + 825 WP_000081311.1 DUF2303 family protein -
P6H86_RS21720 (4392927) 4392927..4393624 + 698 WP_223400810.1 IS1-like element IS1X2 family transposase -
P6H86_RS21725 (4393692) 4393692..4394243 + 552 WP_278008294.1 hypothetical protein -
P6H86_RS21730 (4394280) 4394280..4394561 + 282 WP_001093916.1 pyocin activator PrtN family protein -
P6H86_RS21735 (4394609) 4394609..4394782 - 174 WP_162900362.1 hypothetical protein -
P6H86_RS21740 (4394822) 4394822..4395208 - 387 WP_014640052.1 hypothetical protein Toxin
P6H86_RS21745 (4395238) 4395238..4395747 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
P6H86_RS21750 (4396063) 4396063..4396167 - 105 Protein_4254 tRNA-dihydrouridine synthase -
P6H86_RS21755 (4396530) 4396530..4397270 - 741 WP_001485178.1 DUF2713 family protein -
P6H86_RS21760 (4397261) 4397261..4397515 - 255 WP_001351877.1 protein YjbL -
P6H86_RS21765 (4397833) 4397833..4398348 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
P6H86_RS21770 (4398390) 4398390..4398599 - 210 WP_001030593.1 CsbD family protein -
P6H86_RS21775 (4398715) 4398715..4400040 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
P6H86_RS21780 (4400113) 4400113..4400721 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4349096..4400721 51625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T275997 WP_014640052.1 NZ_CP121157:c4395208-4394822 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT275997 WP_024174200.1 NZ_CP121157:c4395747-4395238 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References