Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2244175..2244813 Replicon chromosome
Accession NZ_CP121157
Organism Escherichia coli strain E89

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P6H86_RS11045 Protein ID WP_000813794.1
Coordinates 2244175..2244351 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P6H86_RS11050 Protein ID WP_001270286.1
Coordinates 2244397..2244813 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H86_RS11025 (2239794) 2239794..2240969 - 1176 WP_001236265.1 BenE family transporter YdcO -
P6H86_RS11030 (2241061) 2241061..2241597 + 537 WP_219383084.1 DNA-binding transcriptional regulator SutR -
P6H86_RS11035 (2241670) 2241670..2243631 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P6H86_RS11040 (2243723) 2243723..2243953 - 231 WP_000494244.1 YncJ family protein -
P6H86_RS11045 (2244175) 2244175..2244351 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P6H86_RS11050 (2244397) 2244397..2244813 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P6H86_RS11055 (2244892) 2244892..2246298 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
P6H86_RS11060 (2246543) 2246543..2247688 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
P6H86_RS11065 (2247706) 2247706..2248719 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
P6H86_RS11070 (2248720) 2248720..2249661 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T275988 WP_000813794.1 NZ_CP121157:2244175-2244351 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT275988 WP_001270286.1 NZ_CP121157:2244397-2244813 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References