Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 907907..908561 Replicon chromosome
Accession NZ_CP121157
Organism Escherichia coli strain E89

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag P6H86_RS04385 Protein ID WP_000244777.1
Coordinates 908154..908561 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P6H86_RS04380 Protein ID WP_000354046.1
Coordinates 907907..908173 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H86_RS04360 (903876) 903876..905309 - 1434 WP_001514525.1 6-phospho-beta-glucosidase BglA -
P6H86_RS04365 (905354) 905354..905665 + 312 WP_001514524.1 N(4)-acetylcytidine aminohydrolase -
P6H86_RS04370 (905829) 905829..906488 + 660 WP_000250276.1 hemolysin III family protein -
P6H86_RS04375 (906684) 906684..907664 - 981 WP_001514522.1 tRNA-modifying protein YgfZ -
P6H86_RS04380 (907907) 907907..908173 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P6H86_RS04385 (908154) 908154..908561 + 408 WP_000244777.1 protein YgfX Toxin
P6H86_RS04390 (908601) 908601..909122 - 522 WP_001055874.1 flavodoxin FldB -
P6H86_RS04395 (909234) 909234..910130 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P6H86_RS04400 (910155) 910155..910865 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P6H86_RS04405 (910871) 910871..912604 + 1734 WP_032187585.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T275978 WP_000244777.1 NZ_CP121157:908154-908561 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT275978 WP_000354046.1 NZ_CP121157:907907-908173 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References