Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4391386..4391883 Replicon chromosome
Accession NZ_CP121155
Organism Escherichia coli strain E67

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P6H85_RS21280 Protein ID WP_001173343.1
Coordinates 4391386..4391559 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag P6H85_RS21285 Protein ID WP_000398619.1
Coordinates 4391587..4391883 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H85_RS21270 (4388056) 4388056..4389513 + 1458 WP_061092757.1 dipeptide/tripeptide permease DtpC -
P6H85_RS21275 (4389750) 4389750..4391267 + 1518 WP_000003806.1 lysine--tRNA ligase -
P6H85_RS21280 (4391386) 4391386..4391559 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P6H85_RS21285 (4391587) 4391587..4391883 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P6H85_RS21290 (4392112) 4392112..4392384 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
P6H85_RS21295 (4392396) 4392396..4392626 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
P6H85_RS21300 (4392807) 4392807..4394438 + 1632 WP_061092758.1 sensor histidine kinase -
P6H85_RS21305 (4394435) 4394435..4395154 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T275970 WP_001173343.1 NZ_CP121155:c4391559-4391386 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT275970 WP_000398619.1 NZ_CP121155:c4391883-4391587 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References