Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4274667..4275189 Replicon chromosome
Accession NZ_CP121155
Organism Escherichia coli strain E67

Toxin (Protein)


Gene name relE Uniprot ID V0SDB6
Locus tag P6H85_RS20680 Protein ID WP_001105432.1
Coordinates 4274667..4274957 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag P6H85_RS20685 Protein ID WP_000212715.1
Coordinates 4274947..4275189 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H85_RS20665 (4269830) 4269830..4271485 + 1656 WP_001361372.1 alpha,alpha-phosphotrehalase -
P6H85_RS20670 (4271879) 4271879..4274017 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
P6H85_RS20675 (4274202) 4274202..4274666 + 465 WP_001009180.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P6H85_RS20680 (4274667) 4274667..4274957 - 291 WP_001105432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P6H85_RS20685 (4274947) 4274947..4275189 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P6H85_RS20690 (4275381) 4275381..4275767 - 387 WP_001232253.1 cytochrome b562 -
P6H85_RS20695 (4275823) 4275823..4277175 - 1353 WP_001162172.1 metalloprotease PmbA -
P6H85_RS20700 (4277269) 4277269..4277820 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
P6H85_RS20705 (4277903) 4277903..4279276 - 1374 WP_001219814.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11311.21 Da        Isoelectric Point: 10.0238

>T275968 WP_001105432.1 NZ_CP121155:c4274957-4274667 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYSVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT275968 WP_000212715.1 NZ_CP121155:c4275189-4274947 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SDB6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References