275966

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3678325..3679162 Replicon chromosome
Accession NZ_CP121155
Organism Escherichia coli strain E67

Toxin (Protein)


Gene name itaT Uniprot ID A0A1M0D5U3
Locus tag P6H85_RS17815 Protein ID WP_000227782.1
Coordinates 3678620..3679162 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID B1LJI1
Locus tag P6H85_RS17810 Protein ID WP_001353405.1
Coordinates 3678325..3678636 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P6H85_RS17785 (3673345) 3673345..3674292 + 948 WP_001239437.1 cytochrome o ubiquinol oxidase subunit II -
P6H85_RS17790 (3674314) 3674314..3676305 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
P6H85_RS17795 (3676295) 3676295..3676909 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
P6H85_RS17800 (3676909) 3676909..3677238 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
P6H85_RS17805 (3677250) 3677250..3678140 + 891 WP_000971327.1 heme o synthase -
P6H85_RS17810 (3678325) 3678325..3678636 + 312 WP_001353405.1 DUF1778 domain-containing protein Antitoxin
P6H85_RS17815 (3678620) 3678620..3679162 + 543 WP_000227782.1 GNAT family N-acetyltransferase Toxin
P6H85_RS17820 (3679218) 3679218..3680062 - 845 Protein_3491 tetratricopeptide repeat protein -
P6H85_RS17825 (3680469) 3680469..3681833 + 1365 WP_001000978.1 MFS transporter -
P6H85_RS17830 (3681961) 3681961..3682452 - 492 WP_001138904.1 nucleotide binding protein YajQ -
P6H85_RS17835 (3682620) 3682620..3683531 + 912 WP_000705841.1 2-dehydropantoate 2-reductase -
P6H85_RS17840 (3683494) 3683494..3684084 + 591 WP_001276320.1 protein deglycase YajL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19957.31 Da        Isoelectric Point: 9.1763

>T275966 WP_000227782.1 NZ_CP121155:3678620-3679162 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDIIYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCNFFEHVKIIHRALPIKGVYLDADPAAINFYTRLGFVQLSA
RPNVFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11370.09 Da        Isoelectric Point: 10.4825

>AT275966 WP_001353405.1 NZ_CP121155:3678325-3678636 [Escherichia coli]
MPGKTVALPDIDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0D5U3

Antitoxin

Source ID Structure
AlphaFold DB A0A829G7G3

References